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Article

Transgenic mouse models of amyotrophic lateral sclerosis.

Biochimica et biophysica acta - 1 Jan 2000

Julien Jean-Pierre, Kriz Jasna

Abstract excerpt

The discovery of missense mutations in the gene coding for the Cu/Zn superoxide dismutase 1 (SOD1) in subsets of familial cases was rapidly followed by the generation of transgenic mice expressing various forms of SOD1 mutants. The mice overexpressing high levels of mutant SOD1 mRNAs do develop motor neuron disease but unraveling the mechanisms of pathogenesis has been very challenging. Studies with mouse lines...

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Source

Identifiers

PMID: 16675207
DOI: 10.1016/j.bbadis.2006.03.006

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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