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Article

Mitochondrial proteomic analysis of a cell line model of familial amyotrophic lateral sclerosis.

Molecular & cellular proteomics : MCP - 1 Dec 2004

Fukada Kei, Zhang Fujian, Vien Alexis, Cashman Neil R, Zhu Haining

Abstract excerpt

Mutations in copper-zinc superoxide dismutase (SOD1) have been linked to a subset of familial amytrophic lateral sclerosis (fALS), a fatal neurodegenerative disease characterized by progressive motor neuron death. An increasing amount of evidence supports that mitochondrial dysfunction and apoptosis activation play a critical role in the fALS etiology, but little is known about the mechanisms by which SOD1...

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Source

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Identifiers

PMID: 15501831
DOI: 10.1074/mcp.M400094-MCP200
PMCID: PMC1360176

Genes

SOD1
VDAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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