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Article

Integrative gene-tissue microarray-based approach for identification of human disease biomarkers: application to amyotrophic lateral sclerosis.

Human molecular genetics - 15 Aug 2010

Kudo Lili C, Parfenova Liubov, Vi Nancy, Lau Kimbley, Pomakian Justine, Valdmanis Paul, Rouleau Guy A, Vinters Harry V, Wiedau-Pazos Martina, Karsten Stanislav L

Abstract excerpt

Advances in genomics and proteomics permit rapid identification of disease-relevant genes and proteins. Challenges include biological differences between animal models and human diseases, high discordance between DNA and protein expression data and a lack of experimental models to study human complex diseases. To overcome some of these limitations, we developed an integrative approach using animal models,...

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Source

Identifiers

PMID: 20530642
DOI: 10.1093/hmg/ddq232

Genes

SOD1
CNGA3
CRB1
MMP14
OTUB2
RSPO2
SLK

Variants

Provenance

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