Article

Gardenin A improves cognitive and motor function in A53T-α-syn mice

2023-11-01

Abstract excerpt

Oxidative stress and neuroinflammation are widespread in the Parkinson’s disease (PD) brain and contribute to the synaptic degradation and dopaminergic cell loss that result in cognitive impairment and motor dysfunction. The polymethoxyflavone Gardenin A (GA) has been shown to activate the NRF2-regulated antioxidant pathway and inhibit the NFkB-dependent pro-inflammatory pathway in a Drosophila model of PD. Here,...

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Literature Corpus work: 46885261-b35a-50ea-abd9-7e5b0261360c
DOI: 10.1101/2023.10.27.564401

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