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Article

Non-motor parkinsonian pathology in aging A53T α-synuclein mice is associated with progressive synucleinopathy and altered enzymatic function.

Journal of neurochemistry - 1 Feb 2014

Farrell Kaitlin F, Krishnamachari Sesha, Villanueva Ernesto, Lou Haiyan, Alerte Tshianda N M, Peet Eloise, Drolet Robert E, Perez Ruth G

Abstract excerpt

Aging, the main risk factor for Parkinson's disease (PD), is associated with increased α-synuclein levels in substantia nigra pars compacta (SNc). Excess α-synuclein spurs Lewy-like pathology and dysregulates the activity of protein phosphatase 2A (PP2A). PP2A dephosphorylates many neuroproteins, including the catecholamine rate-limiting enzyme, tyrosine hydroxylase (TH). A loss of nigral dopaminergic neurons...

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Identifiers

PMID: 24117685
DOI: 10.1111/jnc.12481
PMCID: PMC4283050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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