Article

Selective enhancement of fear extinction by inhibiting neuronal adenylyl cyclase 1 (AC1) in aged mice

2024-01-09

Abstract excerpt

<title>Abstract</title> <p>Adenylyl cyclase 1 (AC1) is a selective subtype of ACs, which is selectively expressed in neurons. The activation of AC1 is activity-dependent, and AC1 plays an important role in cortical excitation that contributes to chronic pain and related emotional disorders. Previous studies have reported that human-used NB001 (hNB001, a selective AC1 inhibitor) produced analgesic effects in diffe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 38572737-9dc4-5ff6-bd2b-e5fd12dff2f7
DOI: 10.21203/rs.3.rs-3837762/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Selective enhancement of fear extinction by inhibiting neuronal adenylyl cyclase 1 (AC1) in aged miceDOI 10.21203/rs.3.rs-3837762/v1Read

Sub-chronic peripheral CB1R inhibition enhances cognitive performance and induces hippocampal synaptic plasticity changes in naïve miceSemantic proximity Read

Evaluation of calcium-sensitive adenylyl cyclase AC1 and AC8 mRNA expression in the anterior cingulate cortex of mice with neuropathic painSemantic proximity Read

Reduced activity of Adenylyl Cyclase 1 Attenuates Morphine Induced Hyperalgesia and Inflammatory Pain in MiceSemantic proximity Read

Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity.Semantic proximity Read

Dysfunctional S1P/S1PR1 signaling in the dentate gyrus drives vulnerability of chronic pain-related memory impairmentSemantic proximity Read

Alterations in the emotional and memory behavioral phenotypes of transient receptor potential vanilloid type 1-deficient mice are mediated by changes in expression of 5-HT₁A, GABA(A), and NMDA receptors.Semantic proximity Read

A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.Semantic proximity Read

Suppression of conditioning to ambiguous cues by pharmacogenetic inhibition of the dentate gyrus.Semantic proximity Read

Salient Safety Conditioning Improves Novel Discrimination LearningSemantic proximity Read

Spreading the reduction of fear: A narrative review of generalization of extinction learning in human fear conditioningSemantic proximity Read

Spreading the reduction of fear: A narrative review of generalization of extinction learning in human fear conditioningSemantic proximity Read

Tissue-specific expression of a type I adenylyl cyclase rescues the rutabaga mutant memory defect: in search of the engram.Semantic proximity Read