Article

Obesogenic diet impairs memory consolidation via the hippocampal endocannabinoid system

2025-07-04

Abstract excerpt

Although obesogenic high-fat/high-sugar diets impair memory function in humans and rodents, the underlying mechanisms remain elusive. Given that the brain endocannabinoid system and type-1 cannabinoid receptors (CB 1 R) control memory processes and are overactive under obesogenic conditions, we studied whether the effects of obesogenic diet consumption on memory function are dependent on this system. Using an obj...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5790757e-71c3-5b90-97ab-32f34a18b564
DOI: 10.1101/2025.07.04.663181

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Obesogenic diet impairs memory consolidation via the hippocampal endocannabinoid systemDOI 10.1101/2025.07.04.663181Read

Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1Semantic proximity Read

Sub-chronic peripheral CB1R inhibition enhances cognitive performance and induces hippocampal synaptic plasticity changes in naïve miceSemantic proximity Read

Time-restricted feeding prevents memory impairments induced by obesogenic diet consumption in mice, in part through hippocampal thyroid hormone signalingSemantic proximity Read

Energy Restriction Enhances Adult Hippocampal Neurogenesis-Associated Memory after Four Weeks in an Adult Human Population with Central Obesity; a Randomized Controlled TrialSemantic proximity Read

Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age.Semantic proximity Read

Developmental regulation of fear memories by an obesogenic high-saturated fat/high-sugar dietSemantic proximity Read

The Metabolically Obese, Normal-Weight Phenotype in Young Rats Is Associated with Cognitive Impairment and Partially Preventable with Leptin Intake during Lactation.Semantic proximity Read

Role of mTOR‐regulated autophagy in spine pruning defects and memory impairments induced by binge‐like ethanol treatment in adolescent miceSemantic proximity Read

Endocannabinoids Modulate Olfactory System Development and FunctionSemantic proximity Read

Cognitive impairment and metabolite profile alterations in the hippocampus and cortex of male and female mice exposed to a fat and sugar-rich diet are normalized by diet reversalSemantic proximity Read

Life-long Dietary Restrictions have Negligible or Damaging Effects on Late-life Cognitive Performance: A Key Role for Genetics in OutcomesSemantic proximity Read

Ethanol drinking sex-dependently alters cortical IL-1β synaptic signaling and cognitive behavior in miceSemantic proximity Read