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Cannabinoid receptor 1 positive allosteric modulator ZCZ011 shows differential effects on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice

2024-05-10

Abstract excerpt

The cannabinoid receptor type 1 (CB 1 R) is a promising therapeutic target for various neurodegenerative diseases, including HIV-1-associated neurocognitive disorder (HAND). However, the therapeutic potential of CB 1 R by direct activation is limited due to its psychoactive side effects. Therefore, research has focused on indirectly activating the CB 1 R by utilizing positive allosteric modulators (PAMs). Studi...

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Literature Corpus work
2990574d-5391-573d-ae21-127f7fc009fa
DOI
10.1101/2024.05.10.593514
Open publication

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Cannabinoid receptor 1 positive allosteric modulator ZCZ011 shows differential effects on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male miceDOI 10.1101/2024.05.10.593514
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