Protective Effect of SIRT1 on TGF-β1 Pathway via mTOR in Diabetic Nephropathy

Abstract excerpt

Increasing amounts of evidence show that silent information regulator 2 homolog 1 (SIRT1) expression in mitochondria plays a crucial role in the pathogenesis and development diabetic nephropathy (DN). However, no studies were carried out to evaluate regulation of SIRT1 in TGF-β1/Smad3 deacetylation. In this study, we demonstrated that overexpressing of SIRT1 may decrease TGF-β1 and Smad3 expression in HEK293 cells...

Topics

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• Adenosine and Purinergic Signaling
• Adipose Tissue and Metabolism
• Autophagy in Disease and Therapy
• Biochemical effects in animals
• Calcium signaling and nucleotide metabolism
• Liver Disease Diagnosis and Treatment
• PARP inhibition in cancer therapy
• Sirtuins and Resveratrol in Medicine

Identifiers and source

Literature Corpus work

466e50c5-a703-56e6-98f7-4a7c594f5a20

DOI

10.21203/rs.3.rs-1464098/v1