Article

Analysis of ribosomes from the Wild-type and FMR1 knockout human embryonic stem cells

2024-11-18

Abstract excerpt

Fragile X Messenger Ribonucleoprotein 1 (FMRP) is a multifunctional, multidomain RNA-binding protein whose loss causes Fragile X syndrome. It is also known to associate with ribosomes and modulate translation. In human embryonic stem cells (hESCs), knockout (KO) of the FMR1 gene results in significantly increased protein translation rates and alterations in the 2’-O-methylation patterns of rRNA. To understand the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f147e0ad-aa7b-57b4-896e-aaee64b3a84a
DOI: 10.1101/2024.11.18.624098

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Analysis of ribosomes from the Wild-type and FMR1 knockout human embryonic stem cellsDOI 10.1101/2024.11.18.624098Read

Altering rRNA 2’O-methylation pattern during neuronal differentiation is regulated by FMRPSemantic proximity Read

FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to AutismSemantic proximity Read

Global ribosome profiling reveals that mutant huntingtin stalls ribosomes and represses protein synthesis independent of fragile X mental retardation proteinSemantic proximity Read

FMRP ribonucleoprotein complexes and RNA homeostasis.Semantic proximity Read

Fragile X mental retardation protein is a size-dependent translational activatorSemantic proximity Read

An inappropriate decline in ribosome levels drives a diverse set of neurodevelopmental disordersSemantic proximity Read

Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutationSemantic proximity Read

Ribosomal RNA methylation induced by MYC regulates translationSemantic proximity Read

Visualizing formation of the active site in the mitochondrial ribosome.Semantic proximity Read

Molecular basis of the human ribosomopathy Shwachman-Diamond syndrome.Semantic proximity Read

The ribosome assembly factor Nop53 has a structural role in the formation of nuclear pre-60S intermediates, affecting late maturation events.Semantic proximity Read

CRISPR activation of the ribosome-associated quality control factor ASCC3 ameliorates fragile X syndrome phenotypes in mice.Semantic proximity Read