Article
Genetic Determinants of Somatic Selection of Mutational Processes in 3,566 Human Cancers.
Cancer research - 15 Aug 2021
Guo Jintao, Zhou Ying, Xu Chaoqun, Chen Qinwei, Sztupinszki Zsófia, Börcsök Judit, Xu Canqiang, Ye Feng, Tang Weiwei, Kang Jiapeng, Yang Lu, Zhong Jiaxin, Zhong Taoling, Hu Tianhui, Yu Rongshan, Szallasi Zoltan, Deng Xianming, Li Qiyuan
Abstract excerpt
The somatic landscape of the cancer genome results from different mutational processes represented by distinct "mutational signatures." Although several mutagenic mechanisms are known to cause specific mutational signatures in cell lines, the variation of somatic mutational activities in patients, which is mostly attributed to somatic selection, is still poorly explained. Here, we introduce a quantitative trait,...
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