Article

Germline genomic patterns are associated with cancer risk, oncogenic pathways and clinical outcomes

2019-04-23

Abstract excerpt

<h4>Summary</h4> Germline genetic polymorphism is prevalent and inheritable. So far mutations of a handful of genes have been associated with cancer risks. For example, women who harbor BRCA1/2 germline mutations have a 70% of cumulative breast cancer risk; individuals with congenital germline APC mutations have nearly 100% of cumulative colon cancer by the age of fifty. At present, gene-centered cancer predisp...

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Literature Corpus work: 1c512549-c544-5a71-98df-22fab0a0d259
DOI: 10.1101/616268

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