Article

α-Helix stabilization by co-operative side chain charge-reinforced interactions to phosphoserine in a basic kinase-substrate motif

2021-11-27

Abstract excerpt

How cellular functions are regulated through protein phosphorylation events that promote or inhibit protein–protein interactions (PPIs) is key to understanding regulatory molecular mechanisms. Whilst phosphorylation can orthosterically or allosterically influence protein recognition, phospho-driven changes in the conformation of recognition motifs are less well explored. We recently discovered that clathrin heavy...

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Literature Corpus work: 46572877-4a89-5997-9ef6-c61d2e545688
DOI: 10.1101/2021.11.27.470016

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α-Helix stabilization by co-operative side chain charge-reinforced interactions to phosphoserine in a basic kinase-substrate motifDOI 10.1101/2021.11.27.470016Read

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