Article

CD1a-Mediated Presentation of Canonical Microbial Peptides to T Cells

2026-05-09

Abstract excerpt

<h4>SUMMARY</h4> Langerhans cells express the nonpolymorphic antigen-presenting molecule CD1a, positioning them as contributors to host immunity against Mycobacterium leprae in human leprosy. CD1a was originally shown to present non-canonical lipopeptide antigens such as dideoxymycobactin and chemically diverse hydrophobic ligands. Here, we generated CD4⁺ T cell lines from leprosy lesions that recognized M. lep...

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Literature Corpus work: 462e758b-ca06-5953-ad54-f5a16359d53b
DOI: 10.64898/2026.05.05.723095

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