Article
Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells.
The Journal of clinical investigation - 1 Mar 2004
Hunger Robert E, Sieling Peter A, Ochoa Maria Teresa, Sugaya Makoto, Burdick Anne E, Rea Thomas H, Brennan Patrick J, Belisle John T, Blauvelt Andrew, Porcelli Steven A, Modlin Robert L
Abstract excerpt
Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin. Using leprosy as a model, we investigated whether expression of CD1a and langerin, an LC-specific C-type lectin, imparts a specific functional role to LCs. LC-like DCs and freshly isolated epidermal LCs presented nonpeptide antigens of Mycobacterium leprae to T cell clones derived from a leprosy patient in a CD1a-restricted...
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