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Antigen Discovery: a Postgenomic Approach to Leprosy Diagnosis

20 Dec 2005

Abstract excerpt

Leprosy is an infectious, neurodegenerative disease of humans caused by Mycobacterium leprae. Despite effective control programs, the incidence of leprosy remains stubbornly high, suggesting that transmission may be more common than expected. The rationale of this work was to use bioinformatics and comparative genomics to identify potentially antigenic proteins for diagnostic purposes. This approach defined three...

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PMID: 16368971
DOI: 10.1128/iai.74.1.175-182.2006

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