Article

Comparing the Impact of Systemic Pituitary Adenylate-Cyclase-Activating Polypeptide (PACAP) and Calcitonin Gene-Related Peptide (CGRP) on Motion-induced Nausea and Balance Behaviors in Mice

2024-10-21

Abstract excerpt

Pituitary adenylate-cyclase-activating polypeptide (PACAP), particularly its dominant isoform PACAP-38, is implicated in migraine and represents a promising therapeutic target. We investigated if intraperitoneally delivered (IP) PACAP-38 impacts motion-induced nausea, postural sway, and imbalance in C57BL/6J wildtype mice using the motion-induced thermoregulation, center of pressure (CoP), rotarod, and balance bea...

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Literature Corpus work: 5abe70f1-b2a5-5e7b-9254-3c8c3e12185a
DOI: 10.1101/2024.10.17.618743

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