Article

Glymphatic function restored by <i>α</i> 1-noradrenergic antagonism alleviates headache allodynia in mice

2026-04-28

Abstract excerpt

Mild traumatic brain injury (mTBI) often leads to migraine-like post-traumatic headache (PTH), yet effective treatments are limited. Clinical and preclinical studies have shown that mTBI disrupts glymphatic transport of cerebrospinal fluid in the brain. We hypothesized that altered glymphatic transport might underlie facial allodynia commonly associated with migraine and PTH. A closed-head impact model was used to...

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Literature Corpus work: 2815ebcc-ac6d-5aaa-a50d-ce2021b4a129
DOI: 10.64898/2026.04.24.720660

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Glymphatic function restored by <i>α</i> 1-noradrenergic antagonism alleviates headache allodynia in miceDOI 10.64898/2026.04.24.720660Read

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