Article

Rac1 deficiency reduces mitochondrial respiratory capacity, impairs fatty acid metabolism and causes muscle wasting

2026-06-17

Abstract excerpt

<h4>Background</h4> The age-related progressive decline in skeletal muscle function is characterised by declining mitochondrial quality control and perturbed fatty acid metabolism, contributing to frailty and increased mortality. The actin cytoskeleton, a key structural component of skeletal muscle, has recently been implicated in mitochondrial anchoring and dynamics. However, the role of actin-regulating protein...

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Literature Corpus work: 460d1299-6004-5da6-b65e-f9fcef86dda8
DOI: 10.64898/2026.06.14.732107

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