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Ankyrin-B modulates mitochondrial fission in skeletal muscle and is required for optimal endurance exercise capacity

25 Aug 2025

Abstract excerpt

Mitochondrial dynamics enable cellular adaptation to fluctuations in energy demand, such as those imposed on skeletal muscle by exercise, metabolic disorders, or aging. Here, we report a novel pathway that modulates mitochondria dynamics in skeletal muscle involving the scaffolding protein ankyrin-B. Rare variants in ankyrin-B, encoded by ANK2, increase risk for cardio-metabolic syndrome in humans and mice. We...

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PMID: 40854882
DOI: 10.1038/s41467-025-62977-3

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