Rare Heterozygous Loss-of-Function Variants in the Human GLP-1 Receptor Are Not Associated With Cardiometabolic Phenotypes.

doi:10.1210/clinem/dgad290

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Article

Rare Heterozygous Loss-of-Function Variants in the Human GLP-1 Receptor Are Not Associated With Cardiometabolic Phenotypes.

The Journal of clinical endocrinology and metabolism - 18 Oct 2023

Melchiorsen Josefine U, Sørensen Kimmie V, Bork-Jensen Jette, Kizilkaya Hüsün S, Gasbjerg Lærke S, Hauser Alexander S, Rungby Jørgen, Sørensen Henrik T, Vaag Allan, Nielsen Jens S, Pedersen Oluf, Linneberg Allan, Hartmann Bolette, Gjesing Anette P, Holst Jens J, Hansen Torben, Rosenkilde Mette M, Grarup Niels

Abstract excerpt

CONTEXT: Lost glucagon-like peptide 1 receptor (GLP-1R) function affects human physiology. OBJECTIVE: This work aimed to identify coding nonsynonymous GLP1R variants in Danish individuals to link their in vitro phenotypes and clinical phenotypic associations. METHODS: We sequenced GLP1R in 8642 Danish individuals with type 2 diabetes or normal glucose tolerance and examined the ability of nonsynonymous variants...

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Identifiers

PMID: 37235780
DOI: 10.1210/clinem/dgad290
PMCID: PMC10584003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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