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TET2-mediated ECM1 hypomethylation promotes the neovascularization in active proliferative diabetic retinopathy

3 Jan 2024

Abstract excerpt

BACKGROUND: Studies have shown that tet methylcytosine dioxygenase 2 (TET2) is highly expressed in diabetic retinopathy (DR), which reduces the DNA methylation of downstream gene promoters and activates the transcription. Abnormally expressed TET2 and downstream genes in a high-glucose environment are associated with retinal capillary leakage and neovascularization. Here, we investigated the downstream genes of...

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PMID: 38172938
DOI: 10.1186/s13148-023-01619-1

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