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Article

Colchicine prevents accelerated atherosclerosis in TET2-mutant clonal haematopoiesis.

European heart journal - 14 Nov 2024

Zuriaga María A, Yu Zhi, Matesanz Nuria, Truong Buu, Ramos-Neble Beatriz L, Asensio-López Mari C, Uddin Md Mesbah, Nakao Tetsushi, Niroula Abhishek, Zorita Virginia, Amorós-Pérez Marta, Moro Rosa, Ebert Benjamin L, Honigberg Michael C, Pascual-Figal Domingo, Natarajan Pradeep, Fuster José J

Abstract excerpt

BACKGROUND AND AIMS: Somatic mutations in the TET2 gene that lead to clonal haematopoiesis (CH) are associated with accelerated atherosclerosis development in mice and a higher risk of atherosclerotic disease in humans. Mechanistically, these observations have been linked to exacerbated vascular inflammation. This study aimed to evaluate whether colchicine, a widely available and inexpensive anti-inflammatory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39212933
DOI: 10.1093/eurheartj/ehae546
PMCID: PMC11560281

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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