Article

Mitochondria-Lysosome Crosstalk Shapes Metabolic Transition in Neonatal Enterocytes

2025-09-10

Abstract excerpt

<h4>SUMMARY</h4> The neonatal gastrointestinal tract mediates nutrient absorption and the establishment of immune tolerance to commensal microbiota. In early life, lysosome-rich enterocytes (LREs) in the ileum are necessary for the intracellular digestion of maternal milk proteins. However, the molecular mechanisms sustaining their function remain incompletely characterized. Here, we demonstrate that LRE mitochon...

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Literature Corpus work: 45d4492a-3013-5aa7-ad4c-0f5e084451f2
DOI: 10.1101/2025.09.09.674148

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