Durable sequence stability and bone marrow tropism in a macaque model of human pegivirus infection.

doi:10.1126/scitranslmed.aab3467

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Article

Durable sequence stability and bone marrow tropism in a macaque model of human pegivirus infection.

Science translational medicine - 16 Sept 2015

Bailey Adam L, Lauck Michael, Mohns Mariel, Peterson Eric J, Beheler Kerry, Brunner Kevin G, Crosno Kristin, Mejia Andres, Mutschler James, Gehrke Matthew, Greene Justin, Ericsen Adam J, Weiler Andrea, Lehrer-Brey Gabrielle, Friedrich Thomas C, Sibley Samuel D, Kallas Esper G, Capuano Saverio, Rogers Jeffrey, Goldberg Tony L, Simmons Heather A, O'Connor David H

Abstract excerpt

Human pegivirus (HPgV)-formerly known as GB virus C and hepatitis G virus-is a poorly characterized RNA virus that infects about one-sixth of the global human population and is transmitted frequently in the blood supply. We create an animal model of HPgV infection by infecting macaque monkeys with a new simian pegivirus (SPgV) discovered in wild baboons. Using this model, we provide a high-resolution,...

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Identifiers

PMID: 26378244
DOI: 10.1126/scitranslmed.aab3467
PMCID: PMC4605385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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