Article

Adenomas Are Frequent in PMS2 Lynch Syndrome patients but Rarely Mismatch Repair Deficient

2025-09-02

Abstract excerpt

<h4>Background</h4> Lynch syndrome (LS) predisposes carriers to the accelerated development of colorectal cancer (CRC). Pathogenic PMS2 variant (PV) carriers are believed to have the lowest CRC risk and develop MMR deficiency (dMMR) at a later stage of CRC progression. In addition, the PMS2 adenoma incidence rate is considered lowest among all MMR PV carriers. However, neither the exact adenoma incidence nor the...

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Literature Corpus work: 24939bc5-07c3-54f2-a454-75f5ac0fc475
DOI: 10.1101/2025.09.01.25334843

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