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Plin4 exacerbates cadmium-decreased testosterone level via inducing ferroptosis in testicular Leydig cells

17 Aug 2024

Abstract excerpt

Strong evidence indicates that environmental stressors are the risk factors for male testosterone deficiency (TD). However, the mechanisms of environmental stress-induced TD remain unclear. Based on our all-cause male reproductive cohort, we found that serum ferrous iron (Fe 2 ⁺) levels were elevated in TD donors. Then, we explored the role and mechanism of ferroptosis in environmental stress-reduced testosterone...

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PMID: 39173539
DOI: 10.1016/j.redox.2024.103312

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