Article

Parthenogenote-Derived Brain Unveils the Critical Role of Paternal Genome in Neural Development

2026-01-06

Abstract excerpt

Genomic imprinting, an epigenetic mechanism that governs parent-of-origin–specific gene expression, is essential for mammalian development, yet its role in late-stage development remains unclear due to the lethality of parthenogenetic (Pg) embryos. Here, we establish cell replacement with parthenogenote-derived cells (CReP), a blastocyst complementation strategy that enables survival and tissue-specific contributi...

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Literature Corpus work: 456bef87-7baf-59e2-af2c-d5d93b90b3f6
DOI: 10.64898/2026.01.06.697935

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