Article
Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis.
Nature - 20 Jul 2011
Ferrón Sacri R, Charalambous Marika, Radford Elizabeth, McEwen Kirsten, Wildner Hendrik, Hind Eleanor, Morante-Redolat Jose Manuel, Laborda Jorge, Guillemot Francois, Bauer Steven R, Fariñas Isabel, Ferguson-Smith Anne C
Abstract excerpt
The gene for the atypical NOTCH ligand delta-like homologue 1 (Dlk1) encodes membrane-bound and secreted isoforms that function in several developmental processes in vitro and in vivo. Dlk1, a member of a cluster of imprinted genes, is expressed from the paternally inherited chromosome. Here we show that mice that are deficient in Dlk1 have defects in postnatal neurogenesis in the subventricular zone: a...
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