Article
Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease.
Nature neuroscience - 1 Feb 2016
Johnson Michael R, Shkura Kirill, Langley Sarah R, Delahaye-Duriez Andree, Srivastava Prashant, Hill W David, Rackham Owen J L, Davies Gail, Harris Sarah E, Moreno-Moral Aida, Rotival Maxime, Speed Doug, Petrovski Slavé, Katz Anaïs, Hayward Caroline, Porteous David J, Smith Blair H, Padmanabhan Sandosh, Hocking Lynne J, Starr John M, Liewald David C, Visconti Alessia, Falchi Mario, Bottolo Leonardo, Rossetti Tiziana, Danis Bénédicte, Mazzuferi Manuela, Foerch Patrik, Grote Alexander, Helmstaedter Christoph, Becker Albert J, Kaminski Rafal M, Deary Ian J, Petretto Enrico
Abstract excerpt
Genetic determinants of cognition are poorly characterized, and their relationship to genes that confer risk for neurodevelopmental disease is unclear. Here we performed a systems-level analysis of genome-wide gene expression data to infer gene-regulatory networks conserved across species and brain regions. Two of these networks, M1 and M3, showed replicable enrichment for common genetic variants underlying...
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