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Article

The road to precision psychiatry: translating genetics into disease mechanisms.

Nature neuroscience - 26 Oct 2016

Gandal Michael J, Leppa Virpi, Won Hyejung, Parikshak Neelroop N, Geschwind Daniel H

Abstract excerpt

Hundreds of genetic loci increasing risk for neuropsychiatric disorders have recently been identified. This success, perhaps paradoxically, has posed challenges for therapeutic development, which are amplified by the highly polygenic and pleiotropic nature of these genetic contributions. Success requires understanding the biological impact of single genetic variants and predicting their effects within an...

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PMID: 27786179
DOI: 10.1038/nn.4409
PMCID: PMC9012265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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