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Article

Antagonism of GxxPG fragments ameliorates manifestations of aortic disease in Marfan syndrome mice.

Human molecular genetics - 1 Feb 2013

Guo Gao, Muñoz-García Begoña, Ott Claus-Eric, Grünhagen Johannes, Mousa Shaaban A, Pletschacher Angelika, von Kodolitsch Yskert, Knaus Petra, Robinson Peter N

Abstract excerpt

Marfan syndrome (MFS) is an inherited disorder of connective tissue caused by mutations in the gene for ﬁbrillin-1 (FBN1). The complex pathogenesis of MFS involves changes in transforming growth factor beta (TGF-β) signaling and increased matrix metalloproteinase (MMP) expression. Fibrillin-1 and...

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Share to Aortic Aneurysm, Thoracic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23100322
DOI: 10.1093/hmg/dds439

Genes

EBP
FBN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23100322-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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