Article

Testing the reliability of AI-generated protein structures

2026-06-13

Abstract excerpt

Although AlphaFold2 and its competitors have demonstrated remarkable abilities to predict protein structure, more work is needed to explore the limitations of these methods. Here we investigated the reliability of AlphaFold2 and ColabFold by creating a set of realistic but false protein sequences, using ColabFold to predict their structure, and then asking how often the program produces a high-scoring structure fo...

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Literature Corpus work: e53acd99-5b34-5271-87a4-c8fa77f75393
DOI: 10.64898/2026.06.11.731682

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