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The Clinical Impact of Somatic Copy Number Variations in Patients With Stage IV Wilms Tumor Enrolled in the SIOP 2001 Trial and Study

3 Feb 2025

Abstract excerpt

BACKGROUND: Recent research elucidated the prognostic significance of molecular biology in Wilms tumor (WT) by linking somatic genomic variants (such as gain of chromosome 1q) to unfavorable patient outcomes. This analysis describes the clinical impact of copy number variations (CNV) in tumor samples of WT patients with stage IV disease. METHODS: Tumor samples of 55 WT patients with stage IV disease from the...

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PMID: 39895484
DOI: 10.1002/pbc.31580

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