Article

Mechanisms in the transition from systemic lupus erythematosus to lupus nephritis: A bioinformatics and functional analysis approach

2025-07-02

Abstract excerpt

<title>Abstract</title> <p>Lupus nephritis (LN), a severe renal complication of systemic lupus erythematosus (SLE), represents the primary driver of end-stage renal disease and mortality in SLE populations. Current immunosuppressive therapies carry significant comorbidity risks, underscoring the urgent need for non-invasive biomarkers enabling early LN detection. This study employed integrated bioinformatics appr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 453115e6-4397-562a-92b6-d5c6b98329c6
DOI: 10.21203/rs.3.rs-6250363/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mechanisms in the transition from systemic lupus erythematosus to lupus nephritis: A bioinformatics and functional analysis approachDOI 10.21203/rs.3.rs-6250363/v1Read

Prioritization of Diagnostic and Prognostic Biomarkers for Lupus Nephritis Based on Integrated Bioinformatics AnalysesSemantic proximity Read

Identification of driver genes in lupus nephritis based on comprehensive bioinformatics and machine learningSemantic proximity Read

Immune cell infiltration characteristics and related core genes in lupus nephritis: results from bioinformatic analysisSemantic proximity Read

Identification and Validation of IFI44 as Key Biomarker in Lupus NephritisSemantic proximity Read

Characterizing hub biomarkers for post-transplant renal fibrosis and unveiling their immunological functions through RNA sequencing and advanced machine learning techniquesSemantic proximity Read

Exploration of biomarkers for systemic lupus erythematosus by machine-learning analysisSemantic proximity Read

Immune cell infiltration characteristics and related core genes in lupus nephritis: results from bioinformatic analysisSemantic proximity Read

Identification of Molecular Markers Associated With the Pathophysiology and Treatment of Lupus Nephritis Based on Integrated Transcriptome AnalysisSemantic proximity Read

Exploration of biomarkers for systemic lupus erythematosus by machine-learning analysisSemantic proximity Read

Identification of Key Genes in Systemic Lupus Erythematosus through integrated bioinformaticsSemantic proximity Read

Identification of oxidative stress-related diagnostic marker genes and immune landscape in interstitial cystitis by bioinformatics and machine learningSemantic proximity Read

Regulatory architecture underlying immune dysregulation reconstructed by single-cell multi-omics in lupus nephritisSemantic proximity Read