Article

Anti-TNF therapy for inflammatory bowel disease in patients with neurodegenerative Niemann-Pick disease Type C

2022-01-11

Abstract excerpt

<h4>Background: </h4> Blockade of tumour necrosis factor (anti-TNF) is effective in patients with Crohn’s Disease but has been associated with infection risk and neurological complications such as demyelination. Niemann-Pick disease Type C1 (NPC1) is a lysosomal storage disorder presenting in childhood with neurological deterioration, liver damage and respiratory infections. Some NPC1 patients develop severe Croh...

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Literature Corpus work: 452eed50-498e-52f9-9203-3c8522402067
DOI: 10.12688/wellcomeopenres.16986.1

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