Article
The Ashitaba (Angelica keiskei) Chalcones 4-hydroxyderricin and Xanthoangelol Suppress Melanomagenesis By Targeting BRAF and PI3K.
Cancer prevention research (Philadelphia, Pa.) - 1 Oct 2018
Zhang Tianshun, Wang Qiushi, Fredimoses Mangaladoss, Gao Ge, Wang Keke, Chen Hanyong, Wang Ting, Oi Naomi, Zykova Tatyana A, Reddy Kanamata, Yao Ke, Ma Weiya, Chang Xiaoyu, Lee Mee-Hyun, Rathore Moeez Ghani, Bode Ann M, Ashida Hitoshi, Lippman Scott M, Dong Zigang
Abstract excerpt
Malignant melanoma is an aggressive tumor of the skin and still lacks effective preventive and therapeutic treatments. In melanoma, both the BRAF/MEK/ERK and PI3-K/AKT signaling pathways are constitutively activated through multiple mechanisms, which result in cell-cycle progression and prevention of apoptosis. Therefore, the development of novel strategies for targeting BRAF and PI3K are of utmost importance. In...
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