Article

Large-scale RNA-seq mining reveals ciclopirox triggers TDP-43 cryptic exons

2024-03-30

Abstract excerpt

Nuclear clearance and cytoplasmic aggregation of TDP-43 in neurons, initially identified in ALS-FTD, are hallmark pathological features observed across a spectrum of neurodegenerative diseases. We previously found that TDP-43 loss-of-function leads to the transcriptome-wide inclusion of deleterious cryptic exons in brains and biofluids post-mortem as well as during the presymptomatic stage of ALS-FTD, but upstream...

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Literature Corpus work: 81aaf045-417b-51ea-a926-9e42dc335c2b
DOI: 10.1101/2024.03.27.587011

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