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Article

AT2-intrinsic Z-AAT expression drives conserved inflammatory and proteotoxic stress responses and predisposes to emphysema

2026-04-09

Abstract excerpt

Individuals homozygous for the SERPINA1 “Z” mutation with alpha-1 antitrypsin deficiency (AATD) are highly susceptible to emphysema. This predisposition has classically been attributed to a relative deficiency of circulating alpha-1 antitrypsin (AAT) reaching the lungs and associated protease-antiprotease imbalance. Accumulating evidence suggests that the presence of misfolded Z-AAT protein either in the circulat...

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Literature Corpus work
450428b7-375f-5adb-bf33-afa2dbec1806
DOI
10.64898/2026.04.06.715869
Open publication

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AT2-intrinsic Z-AAT expression drives conserved inflammatory and proteotoxic stress responses and predisposes to emphysemaDOI 10.64898/2026.04.06.715869
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