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Article

Z α1-antitrypsin confers a proinflammatory phenotype that contributes to chronic obstructive pulmonary disease.

American journal of respiratory and critical care medicine - 15 Apr 2014

Alam Samuel, Li Zhenjun, Atkinson Carl, Jonigk Danny, Janciauskiene Sabina, Mahadeva Ravi

Abstract excerpt

RATIONALE: Severe α1-antitrypsin deficiency caused by the Z variant (Glu342Lys; ZZ-AT) is a well-known genetic cause for emphysema. Although severe lack of antiproteinase protection is the critical etiologic factor for ZZ-AT-associated chronic obstructive pulmonary disease (COPD), some reports ha...

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Identifiers

PMID: 24592811
DOI: 10.1164/rccm.201308-1458OC
PMCID: PMC4098095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24592811-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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