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Article

Contributions of alveolar epithelial cell quality control to pulmonary fibrosis.

The Journal of clinical investigation - 1 Oct 2020

Katzen Jeremy, Beers Michael F

Abstract excerpt

Epithelial cell dysfunction has emerged as a central component of the pathophysiology of diffuse parenchymal diseases including idiopathic pulmonary fibrosis (IPF). Alveolar type 2 (AT2) cells represent a metabolically active lung cell population important for surfactant biosynthesis and alveolar homeostasis. AT2 cells and other distal lung epithelia, like all eukaryotic cells, contain an elegant quality control...

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Identifiers

PMID: 32870817
DOI: 10.1172/JCI139519
PMCID: PMC7524463

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