Article
The promise of discovering population-specific disease-associated genes in South Asia.
Nature genetics - 1 Sept 2017
Nakatsuka Nathan, Moorjani Priya, Rai Niraj, Sarkar Biswanath, Tandon Arti, Patterson Nick, Bhavani Gandham SriLakshmi, Girisha Katta Mohan, Mustak Mohammed S, Srinivasan Sudha, Kaushik Amit, Vahab Saadi Abdul, Jagadeesh Sujatha M, Satyamoorthy Kapaettu, Singh Lalji, Reich David, Thangaraj Kumarasamy
Abstract excerpt
The more than 1.5 billion people who live in South Asia are correctly viewed not as a single large population but as many small endogamous groups. We assembled genome-wide data from over 2,800 individuals from over 260 distinct South Asian groups. We identified 81 unique groups, 14 of which had estimated census sizes of more than 1 million, that descend from founder events more extreme than those in Ashkenazi...
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