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Article

Human NLRC4 expression promotes cancer survival and associates with type I interferon signaling and immune infiltration

23 Apr 2024

Abstract excerpt

The immune system can control cancer progression. However, even though some innate immune sensors of cellular stress are expressed intrinsically in epithelial cells, their potential role in cancer aggressiveness and subsequent overall survival in humans is mainly unknown. Here, we show that nucleotide-binding oligomerization domain-like receptor (NLR) family CARD domain-containing 4 (NLRC4) is downregulated in...

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PMID: 38652550
DOI: 10.1172/jci166085

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