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Article

NLRP3 promotes immune escape by regulating immune checkpoints: A pan-cancer analysis.

International immunopharmacology - 1 Mar 2022

Ding Yue, Yan Yilin, Dong Yihui, Xu Jingyuan, Su Wei, Shi Weijun, Zou Qi, Yang Xiaoping

Abstract excerpt

NLRP3 plays a pathogenic role in tumorigenesis by regulating innate and acquired immunity, apoptosis, differentiation, and intestinal microbes in tumors. Our research aimed to investigate the role of NLRP3 in pan-cancers based on multi-omics data in the TCGA database. Most types of tumors showed increased expression of NLRP3. Among them, the overexpressed NLRP3 in liver hepatocellular carcinoma (LIHC) and ovarian...

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Identifiers

PMID: 35026655
DOI: 10.1016/j.intimp.2021.108512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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