Article

Trilobatin attenuates cerebral ischemia/reperfusion-induced blood-brain-barrier dysfunction by targeting MMP9: The legend of a food additive

2023-02-15

Abstract excerpt

<h4>Background: </h4> and Purpose: Blood-brain barrier (BBB) breakdown is one of the most crucial pathological changes of cerebral ischemia-reperfusion (I/R) injury. Trilobatin (TLB), a naturally occurring food additive, exerts neuroprotective effect against cerebral I/R injury as demonstrated in our previous study. This study was designed to investigate the effect of TLB on disruption of BBB after cerebral I/R in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 16d8f04a-7a61-56aa-845b-dbec1f3cf1bd
DOI: 10.22541/au.167645942.25393053/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Trilobatin attenuates cerebral ischemia/reperfusion-induced blood-brain-barrier dysfunction by targeting MMP9: The legend of a food additiveDOI 10.22541/au.167645942.25393053/v1Read

Trilobatin attenuates blood-brain barrier dysfunction induced by cerebral ischemia reperfusion by targeting MMP9: Involvement of APOE4/CypA/NF-κB signalingSemantic proximity Read

Induction of IRG1 following ischemic stroke promotes HO-1 and BDNF expression to alleviate neuroinflammation and restrain ischemic brain injurySemantic proximity Read

The study of neuroprotective effects and underlying mechanism of Naoshuantong capsule on ischemia stroke miceSemantic proximity Read

Compound porcine cerebroside and ganglioside injections improved anxiety and cognitive dysfunction through the NF-κB pathway in cerebral ischemia-reperfusion injurySemantic proximity Read

The Impact of Environmental Enrichment on Neurological Damage: Mechanistic Study of Ferroptosis Inhibition via Tlr4Semantic proximity Read

<i>Panax notoginseng saponins</i> protect the blood–brain barrier against oxidative stress by activating the Akap12–PI3K/AKT–AQP1 signaling axisSemantic proximity Read

Astragaloside IV alleviates neuronal ferroptosis in ischemic stroke by regulating FTO-m6A-ACSL4 axisSemantic proximity Read

Combining UHPLC-QE-MS mass spectrometry, network pharmacology and molecular docking technology to explore the mechanism of action of TQTMD in the treatment of acute ischemic strokeSemantic proximity Read

Single-Cell RNA Sequencing Unveils Lrg1's Role in Cerebral Ischemia‒Reperfusion Injury by Modulating Various CellsSemantic proximity Read

Treatment of Ischemic Stroke with Wenyang Huayu Formula: network pharmacology analysis and experimental validationSemantic proximity Read

Mogrol Protects Against Hepatic Ischemia–Reperfusion Injury by Preserving Mitochondrial Function Through PI3K/AKT SignalingSemantic proximity Read

Hypothermia Protects Against Ischemic Stroke Through Peroxisome-proliferator-activated-receptor GammaSemantic proximity Read