Article

Investigating the role of ZEB2 in the establishment of neuroepithelial architecture and axon tract formation

2020-01-01

Abstract excerpt

A bioinformatic screen of comparative genomic and transcriptomic datasets identified the transcription factor ZEB2 as a putative regulator of brain size. In this work we show that in both human brain organoids and mouse embryos ZEB2 is expressed in telencephalic neuroepithelial cells (NECs) before the switch to radial glia (RGCs). By establishing a human embryonic stem cell (hESC) model of ZEB2 heterozygous loss-o...

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Literature Corpus work: 44bcf32c-c66b-50f2-88b9-db2fd2085668
DOI: 10.17863/cam.47002

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