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Validation of the p21-Activated Kinases as Targets for Inhibition in Neurofibromatosis Type 2

30 Sept 2008

Abstract excerpt

Neurofibromatosis type 2 (NF2) is a dominantly inherited cancer disorder caused by mutations at the NF2 gene locus. Merlin, the protein product of the NF2 gene, has been shown to negatively regulate Rac1 signaling by inhibiting its downstream effector kinases, the p21-activated kinases (Pak). Given the implication of Paks in tumorigenesis, it is plausible that merlin's tumor suppressive function might be...

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PMID: 18829550
DOI: 10.1158/0008-5472.can-08-0866

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Validation of the p21-Activated Kinases as Targets for Inhibition in Neurofibromatosis Type 2PMID 18829550Read ↗

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