Article

The acidic N-terminus of HHARI and neddylation are essential for the activation and maintenance of RIG-I-mediated type I interferon response

2025-02-06

Abstract excerpt

Human homolog of Ariadne (HHARI) is a RING-between-RING ubiquitin E3 ligase which interacts with cullin-RING E3 ligase (CRL) complexes. HHARI has been implicated in the type-I interferon anti-viral response. However, how HHARI drives interferon signalling is not fully understood and the function of the unique, highly conserved acidic N-terminal domain of the protein is unknown. Here, we show that HHARI stimulates...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 44814050-f2ae-50dd-808e-5d8067f1f3f3
DOI: 10.1101/2025.02.01.636034

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The acidic N-terminus of HHARI and neddylation are essential for the activation and maintenance of RIG-I-mediated type I interferon responseDOI 10.1101/2025.02.01.636034Read

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin‐RING ligase complexesSemantic proximity Read

Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7.Semantic proximity Read

Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction.Semantic proximity Read

Riplet Ubiquitin Ligase Regulates Innate Antiviral Immune Responses Via Lysine 63-Linked Polyubiquitination of RIG-I and LGP2 and is Essential for Protection Against SARS-CoV-2Semantic proximity Read

The ring between ring fingers (RBR) protein familySemantic proximity Read

A Distinct Role of Riplet-Mediated K63-Linked Polyubiquitination of the RIG-I Repressor Domain in Human Antiviral Innate Immune ResponsesSemantic proximity Read

The ubiquitin E3 ligase Huwe1 facilitates viral and self RNA sensing by RIG-I-like receptorsSemantic proximity Read

HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I.Semantic proximity Read

Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate ImmunitySemantic proximity Read

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.Semantic proximity Read

Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins.Semantic proximity Read

Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction.Semantic proximity Read