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Article

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.

EMBO reports - 1 Sept 2008

Friedman Constantin S, O'Donnell Marie Anne, Legarda-Addison Diana, Ng Aylwin, Cárdenas Washington B, Yount Jacob S, Moran Thomas M, Basler Christopher F, Komuro Akihiko, Horvath Curt M, Xavier Ramnik, Ting Adrian T

Abstract excerpt

On detecting viral RNAs, the RNA helicase retinoic acid-inducible gene I (RIG-I) activates the interferon regulatory factor 3 (IRF3) signalling pathway to induce type I interferon (IFN) gene transcription. How this antiviral signalling pathway might be negatively regulated is poorly understood. Microarray and bioinformatic analysis indicated that the expression of RIG-I and that of the tumour suppressor CYLD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18636086
DOI: 10.1038/embor.2008.136
PMCID: PMC2529351

Genes

CYLD
TANK
TBK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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