Article

IL6ST–induced muscarinic receptor opens goblet cell associated antigen passages to suppress alcoholic liver disease

2021-04-03

Abstract excerpt

<title>Abstract</title> <p>Alcohol consumption is the seventh leading risk factor for death worldwide 1 48 and alcoholic liver disease (ALD) is the major cause of liver transplantation in the West 2 49 . Alcohol metabolites can 50 directly damage the liver, but the gut-liver axis also plays an important role in ALD pathogenesis, 51 acting through complex and obscure mechanisms. Although alcohol intake is associat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4466d085-2014-5203-9e86-acc2155e0deb
DOI: 10.21203/rs.3.rs-366644/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

IL6ST–induced muscarinic receptor opens goblet cell associated antigen passages to suppress alcoholic liver diseaseDOI 10.21203/rs.3.rs-366644/v1Read

Frontline defenders: goblet cell mediators dictate host-microbe interactions in the intestinal tract during health and diseaseSemantic proximity Read

Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon.Semantic proximity Read

CD73 generated extracellular adenosine promotes resolution of neutrophil-mediated tissue injury and restrains metaplasia in pancreatitisSemantic proximity Read

Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic interventionSemantic proximity Read

Monoclonal Antibodies Against Mature Interleukin-18 Ameliorate Colitis and Repair Goblet Cell FunctionSemantic proximity Read

A 3-Dimensional bioprinted human gut-liver axis model for studying Alcoholic Liver DiseaseSemantic proximity Read

Sortilin Deficiency Reduces Ductular Reaction, Hepatocyte Apoptosis, and Liver Fibrosis in Cholestatic-Induced Liver Injury.Semantic proximity Read

The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis.Semantic proximity Read

Goblet cell LRRC26 regulates BK channel activation and protects against colitis in miceSemantic proximity Read

Review of experimental animal models of biliary acute pancreatitis and recent advances in basic research.Semantic proximity Read

RAMP1 in Kupffer cells is a critical regulator in immune-mediated hepatitisSemantic proximity Read

Perforin and granzymes work in synergy to mediate cholangiocyte injury in experimental biliary atresiaSemantic proximity Read